| 2021-12-07 | Andre Hutson | Shooting | 1700 block of Wayne Lanter Avenue |
| 2021-11-11 | Robin M. Mendez | Unspecified | 100 block of Rainbow Drive |
| 2021-10-27 | Tyler Timmins | Shooting | Illinois Route 111 and Chain of Rocks Road |
| 2021-08-04 | Brian Pierce Jr. | Vehicular | McKinley Bridge |
| 2021-08-02 | Ahmaad R. Nunley | Shooting | Highway 3 and Niedringhaus Avenue |
| 2021-07-16 | Antwone L. Brown | Shooting | 500 block of washington avenue |
| 2021-06-25 | Delas M. Carter | Shooting | 1500 block of Madison Avenue |
| 2021-06-07 | Gerald K. Wiley | Shooting | 1700 block of Fourth Street |
| 2021-05-22 | Kody Waters | Police | 819 Edwardsville Road |
| 2021-05-08 | Tykeisha Marie Dixon | Unspecified | Illinois 143 and Goshen Road |
| 2021-05-02 | DeAndre Brewster | Shooting | 200 block of East Elm Street |
| 2021-02-13 | Robert Woods | Shooting | 100 block of East 11th Street |
| 2021-02-01 | Leonard "James" Ebrey | Stabbing | 2300 block of Wedgewood Drive |
| 2021-02-01 | Robert B. Andrews | Stabbing | 2300 block of Wedgewood Drive |
| 2021-01-14 | Moneer Damra | Shooting | Route 157 and Interstate 270 |