| 2022-10-31 | Unknown | Child | 3800 block of Oregon Avenue |
| 2022-11-22 | DeVonne Wilson | Vehicular | 4000 block of Meramec Street |
| 2022-11-22 | Ayanna Woods | Vehicular | 4000 block of Meramec Street |
| 2022-11-30 | Stanley Atherton Jr. | Shooting | Gasconade Street and California Avenue |
| 2022-10-26 | Richard "Rick" Wader | Unspecified | 3933 South Broadway |
| 2022-10-14 | Tabitha Peppers | Shooting | 3600 block of Montana Street |
| 2022-09-20 | Richard Lee Brock | Shooting | 3900 block of Chippewa Street |
| 2022-08-21 | Deionta McCurry | Shooting | 3600 Montana Street |
| 2022-08-18 | Leroy Dorian Hulesy | Shooting | 4000 block of Iowa Avenue |
| 2022-07-03 | Kelsey Williams | Shooting | 4600 block of Tennessee |
| 2022-05-16 | William Buchanan | Shooting | 3700 block of Meramec Street |
| 2022-02-20 | Anitra Whitehead | Asphyxiation | 3900 block of Dunnica Avenue |
| 2022-02-09 | Timothy Ferguson | Shooting | 3900 block of Minnesota Avenue |